The plants of the genus Gerbera (Compositae) are the ornamentally,medicinally,and economically important plants,and rich in coumarins,especially,the characteristic 4-hydroxy-5-methylcoumarin derivatives,which derived from the acetate-malonate pathway.Thus,this review focus on the biosynthetic pathway,chemical structure classifications,chemical structures,and bioactivities of 4-hydroxy-5-methylcoumarin derivatives that derived from the acetate-malonate pathway from the Gerbera plants,providing a solid basis for the further research and development of this genus.