The transformation rule of 6-gingerol and the effect of 6-gingerol transformation on antioxidant activity in vitro were studied by sand frying and simulated processing combined with antioxidant test in vitro.The UPLC was used to determine the contents of 6-gingerol,6-shogaol and zingerone in dried ginger and different sand frying processes;The contents of 6-gingerol and its transformation products 6-shogaol and zingerone were investigated under different temperature and time conditions by simulating processing 6-gingerol monomer with oil bath heating;In vitro antioxidant activities of processed ginger samples and 6-gingerol simulated processed products were determined by different sand frying processes,and the correlation between 6-gingerol content and antioxidant activities was analyzed by SPSS 23.0.The results showed that with the prolongation of sand frying time and the increase of temperature,the content of 6-gingerol in ginger samples decreased gradually,and the content of 6-shogaol and zingerone increased gradually.The simulated processing confirmed that 6-gingerol could be partially converted into 6-shogaol and zingerone after oil bath heating.There was a significant positive correlation between 6-gingerol content and antioxidant activity in simulated processed samples.The experimental results provided a reference for revealing the processing mechanism and optimization of processing technology of ginger.