In nature,polysaccharides are widely distributed in a variety of organisms.Plant polysaccharides,animal polysaccharides and microbial polysaccharides are the main three types of polysaccharides.Since 1960,people have successively discovered that polysaccharides have a variety of pharmacological effects,including anti-oxidation,anti-tumor,anti-infection,anti-inflammatory,anti-depression,regulating immune function,and reducing blood sugar and blood lipids.Influenza virus is a representative species of orthomyxoviridae that causes influenza,and the surface antigens of influenza virus are prone to mutate,leading to a worldwide pandemic.Seasonal influenza causes huge economic losses and also poses a threat to human health.In order to effectively control the influenza pandemic,antiviral treatment and prevention have become research hotspots and urgent clinical needs.The inhibitory effect of polysaccharides on influenza viruses has received widespread attention.This article reviews the research of polysaccharides against influenza virus,in order to discuss the mechanism of action of different polysaccharides against influenza virus,and propose prospects for the future research,development and wide application of polysaccharides.