To optimize the microwave process of honey roast Astragalus membranaceus by response surface method (RSM) combined with overall desirability.On the basis of single factor experiment,the response surface optimization experiment was conducted on the four factors of honey roast A. membranaceus,honey dosage,stuffy moist time,processing time and microwave power by taking the total flavonoids,total saponin extraction rate,water-soluble extract content and the total evaluation normalization value of the appearance of the decoction pieces as evaluation indicators.Finally,the optimum technological conditions were obtained as follows:processing time of 81 s,honey dosage of 34%,microwave power of 82%,moist time of 6.1 h.At this time,the contents of total flavone,saponins,water-soluble extract were 0.351 0%, 0.589 4%, 24.71% and appearance score of slices was 90 respectively.The processing technology of microwave honey roast A. membranaceus was reasonable,stable and feasible,which can provide a theoretical reference for the industrial production of honey roast A. membranaceus, and also provide new research ideas and methods for the processing of other traditional Chinese medicines.