Broussonin C is a 1,3-diarylpropane compound isolated from Broussonetia papyrifera,which has good tyrosinase inhibitory activity.Using 2,4-dihydroxybenzaldehyde as the starting material,broussonin C has been successfully synthesized in six steps,which achieves the first total synthesis of broussonin C.The method is easy to operate with high yield.Meanwhile,it was found that the compound with non-isopentenyl fragment has better activities,which effectively simplified its structure.