NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2024, Vol. 36 ›› Issue (8): 1432-1444.doi: 10.16333/j.1001-6880.2024.8.017

Previous Articles     Next Articles

Research progress on chemical components and pharmacological effects of Achyranthes bidentata and prediction and analysis of its quality markers

HAN Yong-guang1,TAN Yan-lan1,ZHANG Chao-yun2,BIAN Hua2*   

  1. 1Colleges of Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China;2 Henan Key Laboratory of Zhang Zhong-jing Formulae and Herbs for Immunoregulation,Nanyang Institute of Technology,Nanyang 473004,China
  • Online:2024-08-28 Published:2024-08-29

Abstract:

Achyranthes bidentata is listed as the top grade in the Shennong Herbal Classic.In recent years,domestic and foreign studies have confirmed there are many types chemical in A. bidentata,including steroids,triterpenoid saponins,polysaccharides and essential oil,which have anti-inflammatory and analgesic effects,immune regulation,anti osteoporosis and cardiovascular protection.Based on the plant′s phylogenetic relationship,the effectiveness of its chemical components,the detectability of its chemical composition and changes of chemical components after processing are made on the potential quality markers (Q-Marker) of A. bidentata.It was preliminarily predicted that achyranterone A, 25R-inokosterone,25S-inokosterone,oleanolic acid-3-O-β-D-(6′-butyl ester)-glucuronopyranoside,oleanolic acid-3-O-β-D-(6′-methyl ester)-glucuronopyranoside and hydroxyecdysone etc.can be potential quality markers of A. bidentata.This review aims to provide the scientific evidence for establishing the quality control and further studying its pharmacological effects of A. bidentata.

Key words: Achyranthes bidentata, chemical composition, pharmacological effect, quality markers

CLC Number: