Wound healing is a dynamic and complex repair process, including inflammation, proliferation, and tissue remodeling. The stages are interrelated, and various unstable factors make wound healing more complicated and more difficult. In recent years, research reports on the treatment of wound injuries by traditional Chinese medicine and related preparations have gradually increased. This article searches domestic and foreign literature in recent years, summarizes the intervention effect of traditional Chinese medicine on wound healing, and provides new ideas and directions for traditional Chinese medicine to promote wound healing. Relevant literature on the regulation of signaling pathways by traditional Chinese medicine and its preparations in wound healing was searched through the literature, and summarized and analyzed. The way and time of wound healing depend on the degree of body injury, tissue regeneration ability, necrotic tissue, foreign body infection and other factors. Local debridement, surgical repair, anti-infection, and drug intervention are the main ways to treat wound healing. Since infection, drug resistance, pro-inflammatory cytokines and other highly expressed factors will affect the normal healing process of the wound, external force intervention is often required. Traditional Chinese medicine has a long history of treating various wound defects. From the perspective of the whole, it regulates growth factors (vascular endothelial growth factor, epidermal growth factor, fibroblast growth factor, transforming growth factor, etc.) and multiple signals through traditional Chinese medicine and related preparations. Pathways (Wnt/β-catenin, PI3K/Akt, PINK1/Parkin, Notch, TGF-β/Smad, etc.), accelerate the regeneration of blood vessels and granulation tissue, inhibit inflammation, reduce hypertrophic scars, and promote wound healing in various ways. The main direction of disease development is the research of traditional Chinese medicine, and the clinical treatment of traditional Chinese medicine for wounds can add more theoretical basis and reference.