Abstract: Oleanolic acid is a pentacyclic triterpenoids widely distributed in the nature which possesses various important bioactivities.Glycosylated modifications of oleanolic acid at C3OH,C17COOH and C12=C13,can not only improve its low polarity,poor solubility in water,and low bioavailability,but also greatly enhance or increase biological activity.The structure of sugar chain groups in synthetic saponin and certain specific groups are key parts of the activities.In this paper,the structure and biological activities of 205 synthetic oleanane type saponins were reviewed,and the structureactivity relationships were discussed between glycosylation type,quantity,connection,location,and special groups and αglucosidase inhibitory activity,hemolytic activity,cancer inhibitory activity,antimicrobial activity.It is insight into molecular design ideas to develop new oleanane type drugs (including agrochemicals).

Key words: oleanolic acid, saponin structure, biological activity, structureactivity relationship