Chemical Constituents with α-Glycosidase Inhibiting Activity from the Bark of Broussonetia papyrifera

Abstract

Abstract:

The α-glycosidase inhibitors were isolated and identified from the bark of Broussonetia papyrifera. By solvent extraction and column chromatography, six compounds were isolated from ethanolic extracts of this plant for the first time and identified as broussonetine A (1), broussonetinine A (2), broussonetinine B (3), liriodendrin (4), butyrospermyl acetate (5), and daucosterol (6) by spectral evidence. Activity assay indicated that compounds 1-3 had strong glycosidase inhibiting activities with IC₅₀ value of 0.530, 0.445, and 0.460 mg/ml, respectively.

Key words: Broussonetia papyrifera, broussonetine A, broussonetinine A, broussonetinine B, glycosidase inhibitor

BAO Ling, CUI Wen-Feng, YU Jian-Ping, YU Kai, WANG Ming-Kui. Chemical Constituents with α-Glycosidase Inhibiting Activity from the Bark of Broussonetia papyrifera[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2010, 23(6): 934-936.

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