Alkaloid against Ischemia/Reperfusion Injury from Seeds of Hippophae rhamnoides Linn.

Abstract

Abstract:

Three alkaloids were isolated from the ethanol extract of Seed of Hippophae rhamnoides Linn and identified as 5-hydroxy-3-(2-Hydroxyethyl) indole (1), 5-hydroxytryptamine (2), and shepherdine (3) by ¹H and ¹³C NMR spectroscopic analyses. Neonatal rat cardiocytes were cultured and model of ischemic/reperfusion (I/R) was established. The results showed three alkaloids have protective effects against the neonatal rat cardiocytes ischemia/reperfusion injured, and compounds 1 and 3 were isolated for the first time from this plant.

Key words: Hippophae rhamnoides Linn Seed, alkaloid, ischemic/reperfusion

XU De-Ping, HU Chang-Ying, MEI Jin-Long, TANG Nian-Chu, ZHAO Chen-Wei. Alkaloid against Ischemia/Reperfusion Injury from Seeds of Hippophae rhamnoides Linn.[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2010, 23(6): 937-939.

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Alkaloid against Ischemia/Reperfusion Injury from Seeds of Hippophae rhamnoides Linn.

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