α-Glucosidase Inhibitory Activity of Tamarix chinensis Lour. and Tamarix ramosissima Ledeb. in Nei Meng-gu

Abstract

Abstract:

The α-glucosidase inhibitory activities of different extracts from two species Tamarix in Nei Meng-gu were screened and compared with acarbose as positive control in vitro by the 96-microplate-based method for the first time. The results showed that six extracts from two species Tamarix showed good inhibitory activity, and they were all greatly higher than that of acarbose (IC₅₀ = 1103.01 μg•mL^-1) as positive control. Petroleum ether extract had lower inhibitory activity than that of ethyl acetate extract and methanolic extract in the same plant. Extracts from different plant of same polar solvent had different inhibitory activity. In six extracts, the methanolic extract of T. ramosissima and ethyl acetate extract of T. chinensis had the highest inhibitor activity of α-glucosidase (IC₅₀ = 13.36和17.35 μg•mL^-1). The all extracts of two species Tamarix in Nei Meng-gu had good inhibitory activity of α-glucosidase, and inhibitory activity of T. ramosissima was higher than that of T. chinensis. Two plants could be exploited the diabetes drugs as α-glucosidases inhibitors in future.

Key words: Tamarix, T. chinensis, T. ramosissima, α-glucosidase, inhibitory activity

CHANG Xing, CUI Wei-Heng, ZHANG Jun-Ke, WU Yu-Hong, KANG Wen-Yi. α-Glucosidase Inhibitory Activity of Tamarix chinensis Lour. and Tamarix ramosissima Ledeb. in Nei Meng-gu[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2011, 23(1): 146-148.

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