NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2011, Vol. 23 ›› Issue (2): 199-201.

• Article •     Next Articles

Chemical Constituents from the Marine-derived Fungus Rhizopus sp. 2-PDA-61

WANG Fa-zuo1,2 , ZHU Tian-jiao2 , ZHANG Min2 , LIN Ai-qun2 , GU Qian-qun2*   

  1. 1 Key Laboratory of Marine Bio-resources Sustainable Utilization, Research Center for Marine Microbes, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; 2 Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
  • Received:2010-04-26 Online:2011-04-25 Published:2011-10-14
  • Supported by:

    This work was financially supported by the National Natural Science Foundation of China (40906076) and the Shandong Provincial Natural Science Fund (ZR2009CZ016).

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Abstract:

Two cytotoxic cyclicpentapeptides (1 and 2) and four benzene derivatives (3-6) have been isolated from the marine-derived fungus Rhizopus sp. 2-PDA-61. By spectral analysis and comparison the data with those of known compounds, they were identified as malformin C (1), malformin A1 (2), 2, 5-dihydroxyphenylacetic acid methyl ester (3), p-hydroxy phenylethanol (4), p-methyl phenylethanol (5), and p-dimethoxybenzene (6), respectively. Moreover, compounds 1 and 2 displayed moderate cytotoxicities to P388 cell lines, and the IC50 values of them were 1.8 μM and 4.2 μM.

Key words: Rhizopus sp, marine-derived fungi, malformins, benzene derivatives