NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2011, Vol. 23 ›› Issue (4): 647-651.

• Article • Previous Articles     Next Articles

Phytochemical Investigation of Corydalis yanhusuo

SHI Jun-min1,2, HAN Wei-li2,3, YE Wen-cai2,3, Chan Shek-kiu4, WANG Yi-tao1, ZHANG Qing-wen1*   

  1. 1Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau; 2Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632,China; 3Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632,China; 4Faculty of Science and Technology, University of Macau, Taipa, Macau
  • Online:2011-08-25 Published:2011-09-13
  • Supported by:

    This research was financially supported by the Macao Science and Technology Development Fund (029/2007/A2) and Research committee of University of Macau (RG075/06-07S/WYT/ICMS and UL016/09-Y1/CMS/WYT01/ICMS).

Abstract: Seventeen compounds have been isolated from Corydalis yanhusuo W. T. Wang. Their structures were deduced on the basis of their physicochemical properties and spectroscopic data. These compounds, including eleven alkaloids, two anthraquinones, a triterpenoid and three steroids, were identified as dihydrochelerythrine (1), dehydrocorydaline (2), tetrahydrocolumbamine (3), isocorybulbine (4), corydaline (5), tetrahydrocoptisine (6), jatrorrhizine (7), coptisine (8), emodin (9), physcion (10), 3β-hydroxy-olean-11,13(18)-dien-28-oic acid (11), berberine (12), palmatine (13), tetrahydropalmatine (14), stigmasterol (15), β-sitosterol (16), and daucosterol (17). Compounds 9-11 were isolated from genus Corydalis for the first time, and 1 was firstly isolated from this species.

Key words: Corydalis yanhusuo, isoquinoline alkaloid, anthraquinone, triterpenoid

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