NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2011, Vol. 23 ›› Issue (5): 801-804.

• Article • Previous Articles     Next Articles

Cytochalasins from Marine-derived Fungus Xylaria sp.SOF11

CHEN Zi-ming1,2,WANG Zhong-wen1,HUANG Hong-bo1,CHEN Yu-chan3,ZHANG Wei-min3,ZHANG Chang-sheng1,JU Jian-hua1*   

  1. 1The Chinese Academy of Sciences Key Laboratory of Marine Bio-resourses Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology,Guangzhou 510301, China; 2Graduate University of the Chinese Academy of Sciences, Beijing 100049, China; 3Guangdong Institute of Microbiology, Guangzhou 510070, China
  • Received:2011-03-01 Online:2011-10-25 Published:2011-09-26

Abstract: Three cytochalasins were obtained from the fermentation broth of the marine-derived fungus Xylaria sp.SOF11,which was isolated from marine sediment collected from the South China Sea.On the basis of 1H,13C and 2D NMR spectral data,compounds 1-3 were identified as 19,20-epoxycytochalasin Q (1),18-deoxy-19,20-epoxycytochalasin Q (2) and 19,20-epoxycytochalasin C (3).Compounds 1-3 showed weak cytotoxicities against two tumor cell lines MCF-7 and NCI-H460 in a MTT assay.

Key words: marine-derived fungus, Xylaria sp.SOF11, secondary metabolite, cytochalasin

CLC Number: