Synthesis,Characterization,and Antioxidant Activity of Phloretin Isonicotinyl Hydrazone

Abstract

Abstract: To improve the biological activity of phloretin, a novel hydrazone was synthesis with phloretin and isoniazid,and the target compound was characterized by UV, IR, ¹H NMR, ¹³C NMR and elemental analysis, respectively.Reducing power, DPPH and ABTS•+ radical scavenging assays were carried out to evaluate the antioxidant and free radical scavenging abilities of phloretin and its hydrazone. The results showed that the antioxidant and free radical scavenging abilities of hydrazone was stronger than phloretin.

Key words: hydrazone, phloretin, isoniazid, synthesis, antioxidant activity

CLC Number:

R284.3

LI Jing, YU Yan-ying, CAO Shu-wen. Synthesis,Characterization,and Antioxidant Activity of Phloretin Isonicotinyl Hydrazone[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2011, 23(5): 824-827.

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Synthesis,Characterization,and Antioxidant Activity of Phloretin Isonicotinyl Hydrazone

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