Protective Effect of Esterified Phenolic Compounds from Gastrodia elata Blume.on Cerebral Ischemia-reperfusion Injury

NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2011, Vol. 23 ›› Issue (5): 842-845.

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Protective Effect of Esterified Phenolic Compounds from Gastrodia elata Blume.on Cerebral Ischemia-reperfusion Injury

LI Xiu-fang1,SUN Yan-kun2,ZHANG Wei-ming3,DAI Rong1,LIN Qing1*

1Yunnan University of Traditional Chinese Medicine, Kunming 650500, China; 2Yunnan Agricultural University, Kunming 650201, China

Received:2010-09-25 Online:2011-10-25 Published:2011-09-26

Abstract

Abstract: The main aim was to investigate the protective effect of esterified phenolic compounds from Gastrodia elata Blume.on cerebral ischemia-reperfusion injury.The middle cerebral artery occlusion (MCAO) model was used.The neurological score,infarct volume,brain tissue water content,and brain tissue Calmodulin-dependent proteinkinase Ⅱ (CaMKⅡ) expression were evaluated.The results showed that esterified phenolic compounds of G.elata could significantly improve the neurological symptoms,reduce infarct volume and cerebral edema,regulate the expression of CaMKⅡ.Esterified phenolic compounds of G.elata had a significant protective effect on cerebral ischemia-reperfusion injury.

Key words: Gastrodia elata Blume., ethyl acetate extract, cerebral ischemia-reperfusion

CLC Number:

R284.2

LI Xiu-fang, SUN Yan-kun, ZHANG Wei-ming, DAI Rong, LIN Qing. Protective Effect of Esterified Phenolic Compounds from Gastrodia elata Blume.on Cerebral Ischemia-reperfusion Injury[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2011, 23(5): 842-845.

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Protective Effect of Esterified Phenolic Compounds from Gastrodia elata Blume.on Cerebral Ischemia-reperfusion Injury

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