NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2011, Vol. 23 ›› Issue (5): 853-856.

• Article • Previous Articles     Next Articles

Flavonol Derivatives from Caragana leucophloea and Their Antimicrobial and Antioxidant Activities

GAO Hai-feng1,2, ZHENG Bing-bing2, WANG Ji-hua2, SHAN Ti-jiang2, ZHAO Si-feng1, ZHOU Li-gang2*   

  1. 1College of Agronomy, Shihezi University, Shihezi 832003, China; 2College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China
  • Received:2011-04-25 Online:2011-10-25 Published:2011-09-26
  • Supported by:

    This work was co-financed by the grants from the Hi-Tech R&D Program of China (2011AA10A202), and the Special Fund for Agro-Scientific Research in the Public Interest of China (nyhyzx07-022 and 200903052).

Abstract: Three flavonol derivatives have been isolated from the aerial parts of Caragana leucophloea Pojark. (Leguminosae). By means of physicochemical and spectrometric analysis, they were identified as 3-O-methylkaempferol (1), 3-O-methylquercetin (2), and quercetin (3). Among them, 1 exhibited the strongest antibacterial activity with its median inhibitory concentration (IC50) values on Escherichia coli and Ralstonia solanacearum as 9.00 μg/mL and 7.42 μg/mL, respectively, and minimum inhibitory concentration (MIC) values on these two bacteria equally as 12.5 μg/mL. Either 2 or 3 showed stronger antioxidant activity than 1. The IC50 values of 2 and 3 on DPPH reduction were 14.39 μg/mL and 13.64 μg/mL, respectively, and those on β-carotene-linoleic acid oxidation were 10.26 μg/mL and 9.87 μg/mL, respectively. These flavonol derivatives were isolated from this plant species for the first time.

Key words: Leguminosae, Caragana leucophloea, flavonol derivatives, antimicrobial activity, antioxidant activity

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