NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2013, Vol. 25 ›› Issue (12): 1649-1652.

• Article • Previous Articles    

Effects of Orthosiphon stamineus Aqueous Extract on the Learning Memory  and Antioxidant Capacity of D-galactose Induced Aging Mice

WANG Ze-dong1, LI Yi-hang2,3, CHEN Xi2,3,4, LI Guang2,3*   

  1. 1 Department of Acupuncture and Moxibustion,the Firt Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China；2 Yunnan Branch,Institute of Medicinal Plant,Chinese Academy of Medical Sciences,Peking Union Medical College,Jinghong 666100,China; 3 Product Research and Development Key Laboratory of Xishuangbanna National Medicine,Jinghong 666100,China; 4 Institute of Medicinal Plant,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100193,China
  • Online:2013-12-31 Published:2015-01-08

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Abstract: This study was conducted to investigate the anti-aging effect of Orthosiphon stamineus aqueous extract (OSAE).The subacute aging model mice were induced by injecting D-galactose subcutaneously.At the same time,low,medium and high dose of OSAE were administered intragastrically once daily for 4 weeks.Signs of aging were observed.The Moriss Water Maze test was used to evaluate the learning and memory function.The levels of NO,SOD,Na+-K+-ATPase,MAO and MDA in the serum and brain tissue were measured.The results showed that the high and middle dose of OSAE shortened the escape latency of the aging model mice,while prolonged the original platform quadrant swimming time significantly compared with the model group (P<0.01, P<0.05).High and middle dose of OSAE increased the SOD,NO,Na+-K+-ATPase activities of the aging model mice,and decreased the MAO and MDA content significantly (P<0.01, P<0.05).It indicated that OSAE can improve the learning and memory ability and increase antioxidant capacity of aging mice,which may has a good anti-aging effect.

Key words: Orthosiphon stamineus, spray dry powder;aging;learning and memory

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