Synthesis and Fungicidal Activity of α-Pinene based Phenyl thiadiazole Compounds

Abstract

Abstract: Nine novel α-pinene based phenyl thiadiazole compounds 7a-7i were synthesized via a multiple step process using α-pinene as starting material.The synthetic conditions were investigated preliminarily.The targeted compounds were analyzed and characterized by FT-IR, ¹H-NMR, ¹³C-NMR and ESI-MS.The preliminary bioassay showed that the targeted compounds exhibited a certain fungicidal activity,in which compound 7d had inhibition rate of 92.6% (A-class activity level) against Physalospora piricola, and compound 7a had inhibition rate of 91.8% (A-class activity level) against Cercopora rachidicola at the concentration of 50 μg/mL.

Key words: &alpha, -pinene, thiadiazole, synthesis, fungicidal activity

CLC Number:

R284.3

LI Long-sheng, CEN Bo, DUAN Wen-gui*, LIN Gui-shan. Synthesis and Fungicidal Activity of α-Pinene based Phenyl thiadiazole Compounds[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2014, 26(10): 1574-1579.

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Synthesis and Fungicidal Activity of α-Pinene based Phenyl thiadiazole Compounds

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