Abstract: To improve the solubility and antioxidant ability of phloretin,water-soluble methionine was induced to the structure of phloretin,a novel Schiff-base was synthesized with phloretin and methionine.The targeted compound was characterized by UV,IR, ¹H-NMR and MS,and their solubility and antioxidant ability were investigated.In addition,the stabilities of phloretin and phloretin methionine Schiff-base were discussed.The results showed the new phloretin derivative had better solubility and antioxidant ability than phloretin.Furthermore,the derivative was more stable in mediums with different pH values.The result of mice acute oral toxicity test showed the LD₅₀ of phloretin methionine Schiff-base were higher than 5000 mg,suggesting that the targeted compound maybe nontoxic.Therefore it was significant to induce methionine to the structure of phloretin,and to broaden the application of phloretin in food and drugs.

Key words: phloretin, phloretin methionine schiff-base, antioxidant ability, solubility, stability, acute toxicity