Synthesis and Characterization of Glycosylated Biochanin A Derivatives

Abstract

Abstract: In order to improve the metabolic stability and bioavailability of biochanin A,twelve biochanin A derivatives were synthesized from biochanin A via introducing glucose to biochanin A′s 7-OH in a simple way.The synthetic pathway is simple and proceeding under mild conditions with high yield. The structure was characterized by ¹H-NMR,IR and ESI-MS.This study laid a foundation for the further study of the bioactivity of those compounds.

Key words: biochanin A, phase transfer catalysis, glycosylation, synthesis

CLC Number:

O629.9

JING Lin-lin1, FAN Xiao-fei1,2, MA Hui-ping1, FAN Peng-cheng1, JIA Zheng-ping1*. Synthesis and Characterization of Glycosylated Biochanin A Derivatives[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2014, 26(12): 1916-1920.

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Synthesis and Characterization of Glycosylated Biochanin A Derivatives

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