Comparative Study on the Pharmacokinetics of Ferulic Acid in Different Combinations of Rats

Abstract

Abstract: The aim of this study was to investigate the pharmacokinetics of ferulic acid and its different combinations.32 Sprague-Dawley rats were randomly divided into 4 groups:ferulic acid 50 mg/kg,ferulic acid 50 mg/kg + tetramethylpyrazine(TMP)30 mg/kg,ferulic acid 50 mg/kg + tetrahydropalmatine(TET)20 mg/kg and ferulic acid 50 mg/kg +TMP 30 mg/kg + TET20 mg/kg.All rats were given by intragastric administration then blood samples were obtained from fossa orbitalis at several time points.All the concentrations of ferulic acid in plasma were analyzed by HPLC and the data were analyzed by DAS 2.0 program.The results showed that TMP and TET prolonged the action time of ferulic acid in rats,increased the absorption of ferulic acid in rats.

Key words: ferulic acid, compatibility, pharmacokinetics, HPLC

CLC Number:

R285.5

FENG Bin-bin1, ZHANG Jian-hai1, XU Xiao-yu2*. Comparative Study on the Pharmacokinetics of Ferulic Acid in Different Combinations of Rats[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2014, 26(12): 2050-2053.

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Comparative Study on the Pharmacokinetics of Ferulic Acid in Different Combinations of Rats

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