Abstract: This paper studied the protective effect and mechanism of Tribulus terrestris L.combined with oligomeric proanthocyanidins on exercise-induced renal ischemiareperfusion injury of rats.In the experiment,the rats were gavaged with 3 g/kg of T.terrestris and 50 mg/kg oligomeric proanthocyanidins for 56 days and carried out exhaustive swim training.The blood urea nitrogen and other biochemical indexes of rats were then measured.The results showed that eight weeks of overtraining led to exercise-induced renal ischemia-reperfusion in rats.Moreover,the rats’ kidney histopathology was changed significantly and renal function was damaged severely.The blood urea nitrogen and serum creatinine increased,TOM group(P<0.05),OPCOM group(P<0.05),TOPCOM group(P<0.01)lower than the OM group; TOPCOM group(P<0.05)lower than the OPCOM group.SOD activity decreased,TOM group(P<0.05),OPCOM group(P<0.05),TOPCOM group(P<0.01)higher than the OM group;TOPCOM group(P<0.05)higher than the OPCOM group.MDA increased,TOM group(P<0.05),OPCOM group(P<0.05),TOPCOM group(P<0.01)lower than the OM group;TOPCOM group(P<0.05)lower than the OPCOM group.The experimental results showed that T.terrestris and oligomeric proanthocyanidins can enhance the activity of SOD,scavenge oxygen free radicals,and reduce lipid peroxidation,which have a protective effect on exercise-induced ischemia-reperfusion kidneys.

Key words: Tribulus terrestris L., oligomeric proanthocyanidins, exercise-induced ischemia-reperfusion