Abstract: The chemical constituents from the barks of Melia azedarach were isolated by silica gel,reverse phase silica gel and Sephadex LH-20 column chromatography, and their anti-diabetes activities were subsequently evaluated.Eight compounds were obtained and elucidated as 12β,20(S)-dihydroxydammar-24-en-3-one(1)，dammarendiol II 3-O-caffeate(2)，24-methylenecycloartenone(3)，meliavolin(4)，3,20-diacetyl-11-methoxy-1-tigloylmeliacarpinin(5)，methyl-3-formyl-2,4-dihydroxy-6-methyl benzoate(6)，usnic acid(7) and epi-catechin(8) based on their spectra and physiochemical characteristics.Among these,compounds 13,6,and 7 were isolated from this species for the first time.All the tested compounds 25 were inactive against GK,SIRT1 and DPPIV,but compounds 2 showed significant inhibitory activity against human 11β-HSD1 with IC₅₀ value of 94.15 nmol/L.

Key words: Melia azedarach, triterpenoids, GK, SIRT1, DPPIV, 11&beta, -HSD