Five Cucurbitacins from Aquilaria sinensis Peels and Their Cytotoxic Activities

NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2014, Vol. 26 ›› Issue (3): 354-357.

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Five Cucurbitacins from Aquilaria sinensis Peels and Their Cytotoxic Activities

ZHANG Xing1,2, TAO Mei-hua1, CHEN Yu-chan1, GAO Xiao-xia2, TAN Yu-zhi2*, ZHANG Wei-min1*

1 State Key Laboratory of Applied Microbiology,South China(The Ministry-Province Joint Development),Guangdong Open Laboratory of Applied Microbiology, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application,Guangdong Institute of Microbiology,Guangzhou 510070,China; 2 College of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China

Online:2014-03-29 Published:2014-12-08

Abstract

Abstract: Five cucurbitacins were isolated from the peels of Aquilaria sinensis. On the basis of spectral data,their structures were identified as dihydrocucurbitacin E (1),endecaphyllacins B (2),2-O-β-D-glucopyranosylcucurbitacin I (3),cucurbitacin E (4),cucurbitacin I (5).Among them,compounds 1-3 were isolated from plants of the genus Aquilaria for the first time.Compounds 1-5 showed cytotoxic activities against tested human cell lines.

Key words: Aquilaria sinensis, peel, chemical constituent, cucurbitacin, cytotoxic activity

CLC Number:

R284.2

ZHANG Xing1,2, TAO Mei-hua1, CHEN Yu-chan1, GAO Xiao-xia2, TAN Yu-zhi2*, ZHANG Wei-min1*. Five Cucurbitacins from Aquilaria sinensis Peels and Their Cytotoxic Activities[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2014, 26(3): 354-357.

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Five Cucurbitacins from Aquilaria sinensis Peels and Their Cytotoxic Activities

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