NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2014, Vol. 26 ›› Issue (3): 398-402.

• Article • Previous Articles     Next Articles

Anti-lipoperoxidation of Several Organic Polyphenol Acids in vitro

ZHANG Xiao-xiao, ZHANG Shuo, HUANG Xiao-yan, LI Gang, WANG Zhen-hua, MA Cheng-jun*   

  1. College of Life Science,Yantai University,Yantai,264005,China
  • Online:2014-03-29 Published:2014-12-08

Abstract: The natural polyphenol acids are reported to possess strong antioxidative activity.In this study,the effects of seven polyphenol acids including rosmarinic acid,coffeic acid,protocatechuic aldehyde,chlorogenic acid,ferulic acid,salvianic acid and 3-hydroxycinnamic acid,against lipid peroxidation in vitro were investigated. The thiobarbituric acid (TBA) assay was used to evaluate the spontaneous and H2O2 induced lipid peroxidation in rat liver homogenate.The results showed that all seven polyphenol acids possessed strong anti-lipid peroxidation activities.The order of their activities against H2O2 induced lipid peroxidation was rosmarinic acid > coffeic acid > protocatechuic aldehyde > chlorogenic acid > ferulic acid > salvianic acid > 3-hydroxycinnamic acid.The order of their activities against spontaneous lipid peroxidation was rosmarinic acid > protocatechuic aldehyde > chlorogenic acid > coffeic acid > ferulic acid > salvianic acid> 3-hydroxycinnamic acid.The anti-lipid peroxidation of seven kinds of organic acid existed significant differences for their different structure.

Key words: natural organic polyphenolic acids, lipid peroxidation, antioxidant capacity, structure-activity relationship

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