The Antioxidative Effect of Oxytropis falcata Bunge Ethanol Extract on Rats Hearts Against Myocardial Ischemia and Reperfushon Injury

Abstract

Abstract: The article studied the Antioxidant protection of Oxytropis falcata Bunge Ethanol extract,during acute myocardial ischemia-reperfusion in rats.The model of myocardial ischemia/reperfusion injury in rats was employed by ligating theartery of left anterior descending (LAD).After the following reperfusion for 40 minutes,the enzyme activity of CK,LDH,SOD,GSH-Px and the concentration of MDA in rats’ serum were tested.The results showed that the ethanol of O.falcata Bunge can decrease the enzymatic activity of CK,LDH and the concentration of MDA,and can heighten the enzymatic activity of SOD and GSH-Px (P<0.01, P<0.05) as propranolol can. O.falcata Bunge,has the antioxidant protection effects during acute myocardial ischemia/reperfusion in rats in vivo.

Key words: Oxytropis falcata Bunge Ethanol extract, myocardial ischemia-reperfusion injury, antioxidation

CLC Number:

R285.5

LI Zhen1, LIU Ming-cheng2, LI Fu-an1, REN Shi-cun1, MA Jian-bin3, ZHANG De-jun1,2*. The Antioxidative Effect of Oxytropis falcata Bunge Ethanol Extract on Rats Hearts Against Myocardial Ischemia and Reperfushon Injury[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2014, 26(3): 423-426.

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The Antioxidative Effect of Oxytropis falcata Bunge Ethanol Extract on Rats Hearts Against Myocardial Ischemia and Reperfushon Injury

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