Dimeric Naphthopyrones from Penicillium oxalicum, a Fungus Residing in Acrida cinerea

Abstract

Abstract: Six dimeric naphthopyrones were isolated from the fermentation broth extract of Penicillium oxalicum, a fungus residing in Acrida cinerea. On the basis of spectral data and physicochemical properties,they were identified as secalonic acid A (1),asperpyrones A (2),asperpyrones B (3),asperpyrones C (4),asperpyrones D (5) and aurasperone A (6).All the compounds were isolated from the endophytic fungus of Penicillium oxalicum for the first time.Compounds 1 showed significant cytotoxic activity against Hep G2 with IC₅₀ values of 1.1 μM.

Key words: Acrida cinerea, inset gut fungus, Penicillium oxalicum, cytotoxic activity

CLC Number:

R931.77

XU Bang, ZOU Kun, GUO Lin-zhi, LIU Cheng-xiong, CHENG Fan*. Dimeric Naphthopyrones from Penicillium oxalicum, a Fungus Residing in Acrida cinerea[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2014, 26(4): 517-520.

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Dimeric Naphthopyrones from Penicillium oxalicum, a Fungus Residing in Acrida cinerea

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