Synthesis of Podophyllotoxin Derivative and Its in Vitro Antitumor Activities

Abstract

Abstract: The aim of this study was to develop a new synthetic method for the synthesis of podophyllotoxin derivative and to investigate the antitumor activity of the synthesized compound.The podophyllotoxin derivative was synthesized using podophyllotoxin as the starting material through a two-step processes including SN₁ nucleophilic displacement followed by condensationhydrolysis.The targeted compound was identified by ¹H-NMR,MS.The antitumor activity of the compound was investigated by MTT assay.The results showed that the cytotoxicity of the new compound was similar to that of etoposide.

Key words: podophyllotoxin, epipodophyllotoxin, synthesis, antitumor activity

CLC Number:

R914.5

XI Wen-li1, SHI Jun-ping1*, ZHANG Ying1, HOU Bao-feng1, KANG Wen-yi2. Synthesis of Podophyllotoxin Derivative and Its in Vitro Antitumor Activities[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2014, 26(4): 594-596.

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Synthesis of Podophyllotoxin Derivative and Its in Vitro Antitumor Activities

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