NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2014, Vol. 26 ›› Issue (4): 597-600.

• Article • Previous Articles     Next Articles

Xanthine Oxidase Inhibitory Activity of Extracts Obtained from 9 Chinese Herbal Medicines

YANG Dao-mao1*, OUYANG Ming-an2   

  1. 1 Laboratory of Oil and Natural Product,Department of Biotechnology and Bioengineering,Huaqiao University,Xiamen 361021,China; 2 Key Laboratory of Biopesticide and chemistry Biology,Ministry of Education,Fujian Agriculture and Forestry University,Fuzhou 350002, China
  • Online:2014-04-30 Published:2014-11-19

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Abstract: In this study,the xanthine oxidase inhibitory activities of extracts obtained from 9 Chinese herbal medicines (Flos puerariae, Herba selaginellae, root of Herba selaginellae, Orthosiphonari status, Herba centipedae, Alpinia officinarum Hance, Gynostemma pentaphyllum (Thunb.) Makino,Herba abri, Lonicera japonica) were investigated.The results showed that all extracts had significant inhibitory effects under the concentration of 2 mg/mL,and the inhibition rate ranged from 33% to 79%.The half-inhibitory concentrations (IC50) of F.puerariae, O.status, L.japonica were determined to be 0.65,0.96,0.74 mg/mL,respectively.The inhibition type was of competitive-induced mixed inhibition.

Key words: xanthine oxidase inhibitory activity, Chinese herbal plants, IC50, mixed inhibition

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