Abstract: Seventeen phenolic constituents were isolated from the rhizome of Wikstroemia indica using a combination of various chromatographic methods.Their structures were elucidated and identified as wikstromol ( 1),matairesinol (2),syringaresinol (3),pinoresinol (4),isolariciresinol (5),ciwujiatone (6 ),isorhamnetin-3-O-robinobioside (7),wikstaiwanone A (8),wikstaiwanone B (9),kaempferol (10),rutin (11),daphnoretin (12),triumbelletin (13),alnusdiol (14),aloe-emodin-8-O-β-D-glucoside (15),chlorogenic acid (16) and p-hydroxybenzoic acid (17) by physicochemical properties and spectral data including NMR and MS.Compounds 3-9 and 13-16 were isolated from this plant for the first time.The antitumor tests showed compounds 1-4, 6-9 exhibited different activities against colon cancer cell lines SW480 and SW620,in which compound 6 showed most significant activities against the two cell lines.

Key words: Wikstroemia indica, chemical constituents, phenolic compounds, anti-tumor