NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2014, Vol. 26 ›› Issue (6): 943-946.

• Article • Previous Articles     Next Articles

Antioxidant Activity of Scopolin from Solanum cathayanum to SH-SY5Y cells

KONG Yu-shan, HUANG Shao-lan, XIE Ming-xia, XUE Yan-hong, ZOU Kun, LIU Shi-ping*   

  1. Hubei Key Laboratory of Natural Products Research and Development,College of Biology and pharmaceutics, Three Gorges University,Hubei Yichang 443002 ,China
  • Online:2014-06-28 Published:2014-11-12

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Abstract: Solanum cathayanum extracts showed obviously antioxidant activity in previous study.Here,in order to further investigate the active components of S.cathayanum, the monomeric compound scopolin was isolated,purified and structurally identified.The antioxidant effects of scopolin to SH-SY5Y cells under H2O2 oxidative stress were assessed.The results revealed that scopolin had evident antioxidant activity in the nontoxic concentration,similar to that of the positive control vitamin E.Besides,LDH leakage rate decreased obviously,suggested that scopolin had the ability of protecting membrane from injury.0.1 μM of scopolin helped the cells to improve antioxidant content such as superoxide dismutase (SOD) and glutathione (GSH).All the results indicated that scopolin can be developed as a potential anti-nerve degenerative disease drug.

Key words: Solanum cathayanum;scopolin;H2O2, SH-SY5Ycells;antioxidant activity

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