Abstract: In this study,the therapeutic effect of ginsenoside Rb₁ on hypertrophic scar was investigated through the establishment of animal model.A mature hypertrophic scar model on rabbits’ ears was established and 5 hypertrophic scars were made on each rabbit.The hypertrophic scars were separated into 5 groups:blank controlgroup (a), physiological saline group (b),ginsenoside Rb₁ treatment groups:0.2 mg/mL(c),0.4 mg/mL (d) and 1.0 mg/mL(e).The results of HE,VG staining,HI and collagen fiber content showed that ginsenoside Rb₁ can reduce the hyperplasia of scar.Furthermore,immunohistochemistry and situ hybridization were separately usedto test the expression of collagen I,Caspase 3 and mRNA of collagen I.It was found that ginsenoside Rb₁ can promote apoptosis of fibroblast and inhibit collagen hyperplasia.Hence,it was concluded that ginsenoside Rb₁ played an effective role in the inhibition of hypertrophic scar development.

Key words: ginsenoside, hypertrophic scar, rabbit ear scar model