NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (6): 1011-1015. doi: 10.16333/j.1001-6880.2015.06.013

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Chemical Constituents of Petroleum Ether Fraction of the Pericarps of Rosa davurica Pall.and Their Inhibitory Activity on Lipase and α-Glucosidase

LI Xiao-di1, JIANG Hui-min2, HUO Ya-yu2, GAO Yang2, BAO He1, ZHANG Hai-long2*   

  1. 1 Department of Pharmacy,the Second Affiliated Hospital,Xian Jiaotong University,Xian 710004,China; 2 School of Pharmacy,Health Science Center,Xi'an Jiaotong University,Xi'an 710061,China
  • Online:2015-06-30 Published:2015-07-10

Abstract: Twelve compounds were isolated and purified from petroleum ether fraction of the pericarps of Rosa davurica Pall.by silica gel and Sephadex LH-20 column chromatography. Their structures were elucidated on the basis of physicochemical properties and spectroscopic data as nonacosane (1),α-tocopherol (2),diethyl phthalate (3),dibutyl phthalate (4), β-sitosterol (5), α-amyrin(6),uvaol (7),botulin (8),betulic acid (9),19-α-hydroxyursolic acid (10),daucosterol (11) and maltose (12).Compounds 1-3, 6-7 and 12 were isolated from R.davurica for the first time.Petroleum ether fraction showed some inhibitory activity on the pancreatic lipase by fluorescent method and on α-glucosidase from the yeast by 96-microplate based method.

Key words: Rosa davurica Pall., pericarps, chemical constituents, pancreatic lipase, &alpha, -glucosidase

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