Abstract: To develop and utilize the juice of Dendrocalamus brandisii, its composition and molecular mechanism of hypolipidemic effect were investigated.With the biomedical analysis,it was determined that its components include total sugar,flavonoids,phenolics,protein and amino acids with the ratios of 25.3%, 0.085%, 0.35%,11.4% and 8.114%,respectively.Furthermore,amino acids contained seven kinds of essential amino acids.Hyperlipidemia rat models were established by high-fat diet feeding,following with the feeding of D.brandisii to investigate its hypolipidemic effect.The blood was collected from coccygeal vein of rats at different times;the serum lipid levels were further detected.The expression level of LXRα and ABCA1 gene in the liver were quantitatively determined.The results showed that the serum levels of TC and LDL-C were decreased in rats with juice feeding,but the HDL-C level and the gene expression of LXRα and ABCA1 in liver tissue were increased.In conclusion,D.brandisii juice might significantly reduce the blood lipid level and prevent hyperlipidemia may through up-regulating the expression of ABCA1 and LXRα and further promoting the transportation of cholesterol.

Key words: Dendrocalamus brandisii, juice;hypolipidemic;molecular mechanism