Abstract: Acute toxicity test and accumulative toxicity test were conducted to assess the potential toxicity of Chinese sweetgum resin in mice.Its antimicrobial activity was tested by disk diffusion method.The experimental results showed that median lethal dose (LD₅₀) of Chinese sweetgum resin was above 16g/kg.As a kind of actually non-toxic substances,Chinese sweetgum resin was normal emptying and had no accumulative toxicity in mice.The minimum bacteriostatic concentration (MIC) of Chinese sweetgum resin against Escherichia coli, Pseudomonas fluorescens, Staphylococcus aureus and Bacillus subtilis were 0.3125,1.25,0.156 mg/mL and 0.3125 mg/mL.In conclusion,Chinese sweetgum resin had good antibacterial activity with no toxicity.It can be used in the development of food and medicinal products.

Key words: Chinese sweetgum resin, acute toxicity, accumulative toxicity, antimicrobial activity