Abstract: This study was conducted to investigate the effects of Moringa oleifera leaves powder on growth performance,antioxidant and immunity function of blood and liver in Sprague Dawley rats.Forty male Sprague Dawley rats with near weight were randomly allocated to five groups.The rats in the five experimental groups were administered 0 (normal control),0.45,0.9,1.8 and 3.6 g/kg body weight M.oleifera leaves powder via gavage.The preliminary feeding period lasted for 3 days,then all groups were treated by gavage for 21 consecutive days.Rats were fasted for 12 h and were subsequently sacrificed by exsanguination.The organ weights of rats were weighted.Antioxidant and immunity indexes in all the samples were measured.The results showed that M.oleifera leaves powder efficiently decreased the contents of triglyceride (TG),cholesterol (CHOL) ,blood urea nitrogen (BUN) and creatinine (CREA) in rat serum (P<0.05);improved the contents of catalase (CAT),glutathione peroxidase (GSH-Px) and decreased the contents of malondialdehyde (MDA) in the serum and liver of rats (P<0.05); increased serum levels of immunoglobulins A and G (IgA,IgG);increased the concentration of interleukin-10 (IL-10) in the serum and liver of rats;decreased the concentration of proinflammatory factor (IL-1β,IL-6) in the serum and interleukin-17 (IL-17) in the liver (P<0.05).In conclusion, M.oleifera leaves powder had no effect on growth performance,but improved blood metabolism,decreased the levels of blood lipid,urea nitrogen and creatinine in the serum and raised glomerular filtration rate,increased antioxidant and immunity function of blood and liver in Sprague Dawley rats and that a dosage of 0.9~1.8 g/kg(BW) was sufficiently effective.

Key words: Moringa oleifera leaves powder, Sprague Dawley rats, performance, antioxidant, immune