NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2016, Vol. 28 ›› Issue (4): 481-485. doi: 10.16333/j.1001-6880.2016.4.002

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A New Amide Metabolite from Endophytic Plantactinospora sp.NEAU-gxj3

GUO Xiao-wei1,2,ZHANG Ji2,LI Jian-song2,ZHANG Hui3,QI Huan3, XIANG Wen-sheng3,4,WANG Xiang-jing2,WU Li-jun1*,WANG Ji-dong3*   

  1. 1 College of Pharmacy,Harbin Medical University,Harbin 150081,China; 2 School of Life Science,Northeast Agricultural University,Harbin 150030,China; 3 Zhejiang Hisun Pharmaceutical Co.,Ltd.,Taizhou 318000,China; 4 State Key Laboratory for Biology of Plant Diseases and Insect Pests,Institute of Plant Protection,Chinese Academy of Agricultural Sciences,Beijing 100193,China
  • Online:2016-04-30 Published:2016-05-13

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Abstract: A new amide metabolite,(2E,7Z)-9-hydroxy-4,6,8-trimethylnona-2,7-dienamide (1),together with two known manumycin-type compounds,antibiotic U-62162 (2) and salternamide C (3) were obtained from the fermentation broth of endophytic Plantactinospora sp.NEAU-gxj3.Their structures were determined on the basis of spectroscopic analysis,including 1D and 2D NMR as well as ESIMS and comparison with literature data.Bioassay of cytotoxic activities results showed that 2 demonstrated potent cytotoxic activity against human leukemia cell line K562,human lung adenocarcinoma cell line A549 and human liver hepatocellular carcinoma cell line HepG2 with an IC50 value of 6.8,32 μg/mL and 19 μg/mL,respectively.

Key words: Plantactinospora sp., new amide metabolite, manumycin-type antibiotic, antibiotic U-62162, salternamide C

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