Abstract: Based on the results of single factor test,response surface methodology with 3 factors and 3 levels was applied according to Box-Behnken experimental design principle.The experimental programs were designed to investigate the effects of solid-liquid ratio,extraction duration and times of extraction on water extraction of Shenqi Fufang granular (SFG).The results showed that the optimal extraction process was solid /liquid ratio (m/V) 1:10,extracted three times with 60 min each time.Under the optimal conditions,the composite score achieved up to 98.90.This optimized process was stable,reasonable and feasible.It can be used as an effective method for the extraction of other medicinal materials from SFG.

Key words: Shenqi Fufang granule, response surface methodology, ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1, astragaloside