NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2016, Vol. 28 ›› Issue (7): 1024-1028.doi: 10.16333/j.1001-6880.2016.7.007

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Transdermal Behavior of VBE-1 and Its Interference Effect on Skin Pigmentation of Guinea Pig Induced by Ultraviolet B Irradiation

LI Su1,WANG Ting2,DING Jin-song3*   

  1. 1 Department of Pharmacy,Xiangya Hospital,Central South University,Changsha 410008,China; 2 Department of Pharmacy,Hunan Children's Hospital,Changsha 410007,China; 3 Department of Pharmaceutics,School of Pharmaceutical Sciences,Central South University,Changsha 410013,China
  • Online:2016-07-30 Published:2017-01-17

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Abstract: The transdermal permeation characteristics of VBE-1 in solution and suspension were investigated by Franz-type diffusion cell in vitro. The permeation and skin residual amount of VBE-1 were quantified by HPLC,and permeation kinetics parameters were calculated.The lag time was shortened and 24 h skin residual amount was increased by 35% in solution.Transdermal behavior of VBE-1 was optimized.Brownish guinea pig model was used to study the interference effect of VBE-1 gel on skin pigmentation induced by ultraviolet B(UVB)irradiation.The results showed that skin melanin increment of 2% VBE-1 gel was significantly lower than the gel base group.The UVB irradiation induced skin hyperpigmentation was interfered by VBE-1 at higher concentrations.

Key words: VBE-1, transdermal behaviors, skin residual amount, melanin, brown guinea pig

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