Penylpropanoids with Cytotoxic Activity from the Fruits of Melia azedarach

Abstract

Abstract: In this study,a new penylpropanoid dimer,mesendannin A (1),along with 5 known ones (+)-Pinoresinol (2),(-)-Eudesmin (3),(-)-Drodehyrodiconiferylalcohol (4),(-)-Jatrointelignan D (5) and (-)-Dihydrodehyrodiconiferyl alcohol (6) were isolated from the fruits of Melia azedarach. Their structures was elucidated on the basis of spectroscopic methods,especially 2D NMR techniques.Compound 1 showed medium cytotoxic against five human tumor cell lines.

Key words: Melia azedarach, Meliaceae, penylpropanoid, cytotoxic activity

CLC Number:

Q946.91
R284.1

ZENG Fa-gu, SU Qian, DI Ying-tong, HAO Xiao-jiang, . Penylpropanoids with Cytotoxic Activity from the Fruits of Melia azedarach[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2016, 28(8): 1172-1175.

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Penylpropanoids with Cytotoxic Activity from the Fruits of Melia azedarach

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