Abstract: To study anti-inflammatory,analgesic and immunomodulatory effects of Schnabelia tetradonta. The analgesic effect was assessed by hot-plate test.The anti-inflammatory effect were observed by ear edema,peritonitis,air-pouch tests.The effects on the total protein (TP),superoxide dismutase (SOD),nitric oxide (NO),the content of malondialdehyde (MDA),and prostaglandin (PGE-2) level in blood serum were determined,and the immune organ index of ear edema and air-pouch of mice were investigated.The results showed that S.tetradonta produced significantly inhibitory effects on permeability and reduced the total protein content,decreased the levels of NO,PGE-2 and MDA,increased the activities of SOD.Middle-dose and low-dose of S.tetradonta can enhance the pain threshold of mice,inhibit the ear edema,significantly increased the spleen index (P<0.05 or P<0.01).Hence, S.tetradonta had analgesic,anti-inflammatory and immunomodulatory effects.

Key words: Schnabelia tetradonta (Sun) C.Y.Wu et C.Chen, analgesia, anti-inflammation, immunomodulation