Chemical Constituents from the Fruiting Bodies of Boletus pseudoregius and Their Inhibition to Tumor Cell Proliferation

doi:10.16333/j.1001-6880.2017.S.002

Abstract

Abstract: Seven compounds were isolated from fruiting bodies of Boletus pseudoregius by using column chromatography.According the spectral data,they were identified as nicotinic acid (1),adenosine (2),succinic acid (3),ergosteol (4),guanosine (5),cerebroside B (6),Dmannitol (7).By in vitro cytotoxicity screening,compounds 2,4,5 and 7 were found to inhibit the proliferation of k562 tumor cells with IC50 of 76.3,80.4,88.7 and 96.5 μg/mL respectively.Compound 2,5,7 showed inhibition to the proliferations of HepG2 with IC50 of 93.8,98.6,97.1 μg/mL.

Key words: Boletus pseudoregius, secondary metabolites, separation and purification, cytotoxicity

ZENG Fan-qing1,FENG Na2*,ZHANG Jing-song2,ZHEN Qiao-ping1. Chemical Constituents from the Fruiting Bodies of Boletus pseudoregius and Their Inhibition to Tumor Cell Proliferation[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2017, 29(增刊1): 6-10.

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Chemical Constituents from the Fruiting Bodies of Boletus pseudoregius and Their Inhibition to Tumor Cell Proliferation

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