Abstract: In order to investigate the mitigation effect of Jerusalem artichoke inulin on obese mice,the obesity mice model was established by using high-fat feed.Forty model mice were randomly and equally divided into model group,low inulin dose group,high inulin dose group and orlistat group to receive normal saline,low dose of inulin,high dose of inulin and orlistat,respectively,by gavage.Meanwhile,ten mice were selected as blank control group,which received fundamental feed and normal saline.After four weeks,the changes in body weight,hepatopancreas index,triglyceride (TG),total cholesterol (TC),high and low density lipoprotein cholesterol (HDL-C and LDL-C) were evaluated and the liver oil red O staining were compared between the four groups.The results were as follows:Compared with model group,inulin reduced mice weight (lowered 9.03% and 7.77%),total cholesterol (lowered 7.91% and 12.02%),HDL-C/LDL-C (lowered 16.39% and 73.51%) ,hepatopancreas index (lowered 13.81% and 44.20%).The liver slices showed that the number of fat droplets under inulin treatments was less than that of model group.These results indicated that inulin had the mitigation effect on obesity through decreasing total cholesterol,hepatopancreas index and fat droplets as well as increasing HDL-C/LDL-C.

Key words: inulin, obesity, dyslipidemia, mitigation