NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2017, Vol. 29 ›› Issue (10): 1752-1758. doi: 10.16333/j.1001-6880.2017.10.020

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Determination of Geographical Origin of Salvia miltiorrhiza by Multi-element Analysis Combined with Multivariate Statistical Analysis

ZHAO Heng-qiang1, ZHANG Min-min1, ZHAO Zhi-guo1, GENG Yan-ling1, HUANG Lu-qi2, WANG Xiao1*   

  1. 1Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Process Control Research Center of Traditional Chinese Medicine of Shandong Academy of Sciences, Jinan 250014,China; 2National Resource Center for Chinese Materia Medica, State Key Laboratory Breeding Base of Dao-di Herbs, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • Online:2017-10-27 Published:2017-10-27

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Abstract: To explore the feasibility for the discrimination of geographical origin of Salvia miltiorrhiza Bge.by multi-element analysis combined with multivariate statistical analysis.A total of 35 metal elements including rare earth elements were analyzed by ICP-MS.Multivariate statistical analysis including principal component analysis (PCA) and linear discriminate analysis (LDA) were used for the discrimination of S.miltiorrhiza  from different geographical origins.As a result,eighteen elements showed significant differences (P<0.05).LDA gave an overall correct classification rate of 100.0% and cross-validation rate of 85.5%.Therefore,multi-element fingerprinting combined with multivariate statistical analysis can be considered as a powerful tool for authenticating the geographical origin of traditional Chinese medicine.

Key words: Salvia miltiorrhiza Bge., geographical origin, multi-element analysis, multivariate statistical analysis

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