NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2017, Vol. 29 ›› Issue (3): 410-414. doi: 10.16333/j.1001-6880.2017.3.008

• Article • Previous Articles     Next Articles

Antibacterial Secondary Metabolites Produced by Mangrove-derived Actinomycete Stremptmeces costaricanus SCSIO ZS0073

SONG Xian-qin1,JIANG Xin2,SUN Jian-bin1,ZHANG Chun-yan3,4,ZHANG Yun3,LU Lai-chun1*,JU Jian-hua3*   

  1. 1 College of Pharmacy,Third Military Medical University,Chongqing 400030,China;2Shandong  Eye Institute Qingdao Eye Hospintal,Qingdao 266071,China;3CAS Key Laboratory of Tropical  Marine Bioresources and Ecology,Guangdong Key Laboratory of Marine Materia Medica,RNAM Center  for Marine Microbiology,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou  510301,China;4Graduate University of ChineseAcademy of Sciences,Beijing 100039,China
  • Online:2017-03-31 Published:2017-04-06

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Abstract: An actinomycete strain Stremptmeces costaricanus SCSIO ZS0073 producing strongly antibacterial metabolites was isolated from the soil collected in Hongsha park.Guided by antibacterial assay,its fermentation was isolated and purified by Silica gel column,Sephadex LH-20 and HPLC.Three compounds were obtained,which were identified as actinomycin D(1),actinomycin XO-β(2) and fungichromin(3) by MS and NMR spectroscopic analysis.The output of actinomycin D was more than 300 mg/L,even under nonoptimized growth conditions.

Key words: mangorove-derived actinomycetes, antibacterial activity, secondary metabolites, actinomycins, fungichromin

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