NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2017, Vol. 29 ›› Issue (3): 431-434. doi: 10.16333/j.1001-6880.2017.3.012

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Synthesis and DNA-Cleavage Activities of Halogenated Phaitanthrin A Based on Tryptanthrin

GU Yun-qiong1,2,SHEN Wen-ying1,GUO Xue-mei1,HUANG Guo-bao1,LUO Zhi-hui1,TAN Ming-xiong1,2*   

  1. 1 Guangxi Key Laboratory for Agricultural Resources Chemistry and Efficient Utilization(Cultivation Base), Yulin Normal University,Yulin 537000,China,2The State Key Laboratory for the Chemistry and Molecular Engineering  of Medicinal Resources,Guangxi Normal University,Guilin 541004,China
  • Online:2017-03-31 Published:2017-04-06

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Abstract: Tryptanthrin and phaitanthrin A are active alkaloids derived from Strobilanthes cusia, Polygonum tinetorium L.,and Isatis tinctoria L.In this study,halogenated tryptanthrin of 8-bromo-tryptanthrin(1) and 8-iodine tryptanthrin(2) were used as substrate to synthesize 8-Br-Phaitanthrin A(3) and 8-I-Phaitanthrin A(4) under solvothermal conditions.The structures and chiral configuration of the synthesized compounds were determined by 1H NMR, 13CNMR and X-ray diffraction.Spectroscopy and gel electrophoresis had shown that compounds 3 and 4 had a strong cleavage action towards DNA.

Key words: tryptanthrin, phaitanthrin A, DNA cleavage

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