Abstract: A facile one-pot synthesis of α-aminophosphonates is achieved by three-component condensation of dehydroabietylamine,aldehyde and diethyl phosphite using TiO₂ as a catalyst under solvent-free condition.The compounds were characterized by FT-IR,MS and ¹H NMR.The antiviral activity of these α-aminophosphonate derivatives was evaluated against the Herpes simplex virus type I (HSV-1) through the MTT method.Preliminary structure activity relationship analysis suggests that the introduction of α-aminophosphonate group into the skeleton of dehydroabietic acid improves the antiviral activity of the derivatives.On the other hand,substituents of the benzene ring on the α-aminophosphonate group have little influence on the antiviral activity of the derivatives.

Key words: Rosin, Dehydroabietylamine, α-aminophosphonate, antiviral