NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2018, Vol. 30 ›› Issue (增刊1): 79-82.

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Chemical Studies on the Liquid Fermentinai Products from the Penicillic  sp.#br#

WU Xiu1,2, DING Zhang-gui3, KONG Ling-mei1,2, ZHU Hua-jie1*, WEN Meng-liang3*, LI Yan1*   

  1. 1State key laboratory of Phytochemistry and Plant Resources of West of China,Kunming Institute of Botany,Academy of Sciences Kunming 650204,Yunnan China; 2Graduate University of Chinese Academy of Sciences Beijing 100049,China; 3Yunnan Institute of Microbiology,Yunnan University,Kunming 650091,China
  • Online:2018-07-31 Published:2018-07-31

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Abstract: There were 13 liquid fermentinal products isolated from the Penicillic sp.They were identified as Paeonol (1),Orsellinic acid (2),Dibenz［b,e］oxepin-6,11-dione,1,9-dihydroxy-3-(hydroxymethyl)-10-methoxy- (3),Dibenz［b,e］oxepin-6,11-dione,1-hydroxy-3-(hydroxymethyl)-10-methoxy-(4),Janthinone(5),4-(hydroxymethyl)phenol (6),4-hydroxybenzaldehyde (7),1,5-Anhydroxylitol (8),Penicillic acid (9),β-sitosterol (10),Ergosta-5,7,22-trien-3-ol (11),Demethylincisterol A3 (12).Compound 12 showed moderate toxicity against five human tumor cell (HL-60,A549,SMMC-7721,MCF-7,SW480) with IC50 value of 14.29,14.02,13.91,16.45,16.05 μM,respectively.

Key words: Penicillic sp., lactones, Penicillic acid

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