Abstract: To explore the effect of honey in basic fibroblast growth factor 2(FGF₂) and transforming growth factor β1 (TGFβ1) contents in rats skin wound repair,reveal the effect of honey on expression of FGF₂ and TGFβ1,discuss repair mechanism.The skin wound was made by manual molding method,after built;honey was coated on the wound.Serum was taken on first,third,fifth,seventh day after injury,respectively.Enzyme linked immunosorbent (ELISA) was used to detect the contents of FGF₂ and TGFβ1.The control group was built to make comparative observation.The main results were as follows:on the first day,FGF₂ and TGFβ1 in honey group were higher than that of control group (P＜0.05).On the third day,both FGF₂ and TGFβ1 in honey group reached the peak,and the control group also increased compared to that of the first day (P＜0.05).On fifth day,both FGF₂ and TGFβ1 decreased in honey group,while the control group continued to increase,especially FGF₂ was higher than honey group (P＜0.05).On the seventh day,both FGF₂ and TGFβ1 in honey group continued to decrease,while FGF₂ and TGFβ1 continued to increase in control group (P＜0.05).Conclusions could be made,honey accelerated FGF₂ and TGFβ1 expression,strengthened their role in promoting inflammatory reaction,promoting capillaries,promoting epithelial cell growth,and promoting the synthesis of extracellular matrix,prevented the secondary infection of the wound,accelerated wound healing in early stage.In the middle and later stage,honey suppressed granulation tissue formation,reduced the extracellular matrix synthesis,prevented excess matrix deposition,also reduced the risk of pathological scar formation by weaking FGF₂ and TGFβ1 expression.

Key words: honey, skin trauma, basic fibroblast growth factor 2, transforming growth factor β1, repair mechanism